Prenatal SNP-array chromosomal microarray analysis in 3,549 pregnancies: indication-specific yields and clinical implications.

doi:10.1186/s12884-026-09187-x

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Article

Prenatal SNP-array chromosomal microarray analysis in 3,549 pregnancies: indication-specific yields and clinical implications.

BMC pregnancy and childbirth - 1 May 2026

Tao Yilun, Wei Yuefeng, Yao Zerong, Han Dong, Wang Lihong, Song Wenxia, Li Xiaoze

Abstract excerpt

BACKGROUND: SNP-based chromosomal microarray analysis (CMA) is widely used in invasive prenatal diagnosis, yet real-world performance across contemporary referral pathways, especially in the NIPT era, remains incompletely characterized. METHODS: We retrospectively analyzed 3,549 prenatal invasive samples tested by SNP array, and evaluated diagnostic yield overall and by referral indication and ultrasound...

Read the complete abstract on PubMed

Topics

Humans
Female
Pregnancy
Retrospective Studies
Polymorphism, Single Nucleotide
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aneuploidy

Prenatal Diagnosis

Microarray Analysis

Advanced Maternal Age

Ultrasonography, Prenatal

Oligonucleotide Array Sequence Analysis

Chromosome Disorders

DNA Copy Number Variations

Source

Open in PubMed Open full text

Identifiers

PMID: 42067806
DOI: 10.1186/s12884-026-09187-x
PMCID: PMC13531756

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