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Article

Polygonatum sibiricum polysaccharide alleviates irritable bowel syndrome via multidimensional phenotypic improvement and sex-specific gut microbiota modulation in mice.

Journal of ethnopharmacology - 10 Aug 2026

Zhang Juzuo, Li Huanhuan, Tan Jiong, Wu Jiaye, Liu Yiyi, Huang Hongyan, Jiang Jun, Zeng Demiao, Xu Junfei

Abstract excerpt

ETHNOPHARMACOLOGICAL RELEVANCE: Polygonatum sibiricum polysaccharide (PSP), as a major bioactive component of P. sibiricum Delar. ex Redoute (Liliaceae, PS), holds great potential for treating irritable bowel syndrome (IBS). However, its therapeutic effects and mechanisms remain unknown. AIM OF THIS STUDY: IBS is a prevalent functional gastrointestinal disorder. The limitation and adverse effects of current...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42066826
DOI: 10.1016/j.jep.2026.121789

Genes

DRD1
TRPV1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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