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Pervasive suppressors halt the spread of selfish Segregation Distorter in a natural population.

Genetics - 5 Aug 2026

Chang Ching-Ho, Handler Tyler, Fuda Nicholas J, Pascua Danielle, Mouton Taylar, Larracuente Amanda M

Abstract excerpt

Meiotic drivers are selfish genetic elements that subvert Mendelian inheritance to increase their own transmission, yet they are typically found at low frequencies across natural populations. The factors that limit their spread remain unclear. The Segregation Distorter (SD) system, a selfish coadapted gene complex in Drosophila melanogaster, is an excellent model to study this paradox. SD biases its transmission...

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PMID: 42057709
DOI: 10.1093/genetics/iyag108
PMCID: PMC13439715

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