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Gene-Lifestyle Synergy in Diabetic Retinopathy Development.

Ophthalmology - 1 Aug 2026

Yang Shaopeng, Xin Zhuoyao, Liu Baichen, Huang Yu, Zhu Zhuoting, Tan Shaoying, He Mingguang, Tham Yih-Chung, Cheng Ching-Yu, Wang Wei

Abstract excerpt

PURPOSE: To develop a machine learning (ML)-driven polygenic risk score (PRS) for diabetic retinopathy (DR) and evaluate the extent to which lifestyle may mitigate genetic risk. DESIGN: Multicenter, multiethnic cohort study. PARTICIPANTS: 9 1691 participants with DR-free prediabetes/diabetes from the UK Biobank (UKB); and 1119 participants with DR-free diabetes from the Guangzhou Diabetic Eye Study (GDES)....

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PMID: 42055347
DOI: 10.1016/j.ophtha.2026.04.017

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