PhenoNMF: A novel multi-layer matrix factorization framework for age-stratified comprehensive phenotypic similarity analysis.

Abstract excerpt

BACKGROUND: Electronic health record (EHR) data enable deep phenotyping for risk prediction and treatment evaluation; however, many existing approaches lack interpretability and are difficult to interpret and validate. Methods that rely on a single modality and disregard age stratification may obscure differences across life stages and weaken model traceability and generalizability. METHOD: We developed PhenoNMF,...

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