Obesity and insulin resistance trigger the early onset of adolescent-like sexually dimorphic metabotypes in middle childhood.

Abstract excerpt

BACKGROUND: The pathophysiology of obesity and insulin resistance are differentially affected by sexual dimorphisms along lifespan, being female children often at higher metabolic risk although presenting lower obesity rates, whereas puberty induces a switch in their prevalence. However, scarce data is available in middle childhood, when crucial hormonal maturation processes begin. METHODS: In this study, we...

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