Targeted allele frequency tuning in breeding populations via alternative optimum contribution selection.

Abstract excerpt

When managing the rate of genomic inbreeding using genomic relationship matrices, allele frequencies tend to be moved toward the frequencies used for centering genotypes in those matrices. Here, we explore if this behavior could be exploited to purposefully change the frequency of alleles. We test the method in a simulated toy example and in the Friesian horse population to purge deleterious alleles as a case...

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