Ultra-sensitive detection of somatic mutations in androgen receptor conferring resistance to anti-androgen therapy in prostate cancer.

Abstract excerpt

Prostate cancer (PCa) is primarily driven by androgen receptor (AR) signaling, where a potent form of androgen, such as dihydrotestosterone (DHT), binds with AR to promote tumor cell proliferation and survival. Somatic mutations in AR gene are recognized as key predictive indicators of therapeutic resistance to anti-androgen therapy in advanced stages of PCa. To enable minimally invasive detection of these...

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