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Article

Exploring the Associations and Mechanisms Between Antihypertensive Drugs and Urological Tumors: Insights from a Mendelian Randomization Study.

Annals of surgical oncology - 1 Aug 2026

Wang Kun, Yang Feixiang, Dai Wei, Zhang Xiangyu, Wang Yuanyuan, Liu Tianrui, Li Hao, Cheng Andong, Meng Jialin, Chen Yiding

Abstract excerpt

BACKGROUND: Hypertension is a risk factor for urological tumors. However, the impact of antihypertensive drugs on these tumors is unclear. METHODS: We used summary statistics from genome-wide association studies (GWASs) of urological tumors, along with expression data for antihypertensive drug target genes from GWASs and eQTLGen. We employed two-sample Mendelian randomization and summary-based Mendelian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42012738
DOI: 10.1245/s10434-026-19698-8

Genes

PPARG
TAPBPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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