Synthetic Niches Enable Coculture Bioprocessing but Are Prone To Mutational Escape.

Abstract excerpt

Stabilizing microbial cocultures is a central challenge for bioproduction. While division of labor between strains can enhance efficiency, it often results in population instability over time. Classical strategies, including cross-feeding, quorum sensing, and toxin-antitoxin modules, often rely on complex ecological interactions that are difficult to predict or maintain under bioprocess conditions. We report the...

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