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Pleomorphic Carcinoma With EGFR and Concomitant Mutations Transformed From Lung Adenocarcinoma: A Case Report.

Cancer reports (Hoboken, N.J.) - 1 Apr 2026

Akazawa Yuki, Sato Takashi, Yagami Yuri, Kesen Yurika, Furo Tomohiro, Watanabe Atsuko, Endo Jumpei, Nakano Maito, Kurata Hiroto, Matsuo Hiromi, Nakahara Yoshiro, Sasaki Jiichiro, Naoki Katsuhiko

Abstract excerpt

BACKGROUND: Transformation to small cell carcinoma, squamous cell carcinoma, and rarely, pleomorphic carcinoma (PC) has been reported to be found in EGFR-mutated lung cancer with acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). However, evidence for underlying factors including genomic profiles associated with PC transformation has been lacking. CASE: We report a case of EGFR-mutated lung...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42002533
DOI: 10.1002/cnr2.70546
PMCID: PMC13092422

Genes

EGFR
PC
BRAF
KRAS
NF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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