New understanding and treatment of adult mitochondrial dysfunction: an example of personalized precision medicine.

doi:10.1016/j.amjmed.2026.04.018

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Article

New understanding and treatment of adult mitochondrial dysfunction: an example of personalized precision medicine.

The American journal of medicine - 1 Oct 2026

Esnaola Gabriela R, Goetzl Edward J

Abstract excerpt

The principal cellular energy-generating pathways of mitochondria used to produce adenosine triphosphate (ATP) are oxidative phosphorylation and β-oxidation of fatty acids. Under anaerobic conditions, glycolysis in the cytoplasm is an alternative mechanism for production of ATP. Mitochondrial diseases result from one or more of the over 350 mutations in mitochondrial DNA (10%) or nuclear DNA (90%) that cause...

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DNA, Mitochondrial
Mitochondria
Mitochondrial Diseases
Mutation
Oxidative Phosphorylation
Precision Medicine

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PMID: 42002194
DOI: 10.1016/j.amjmed.2026.04.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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