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BMP15 regulates proliferation of sheep granulosa cells with different genotypes via the TGF-β/SMAD signaling pathway.

Journal of ovarian research - 18 Apr 2026

Liu Qing, Cao Guiling, Li Wentao, Liu Ziyi, Wang Peng, He Xiaoyun, Liu Yufang, Chu Mingxing

Abstract excerpt

BMPR1B is considered to be the main effector gene affecting polytocous trait in sheep and other animals, and co-regulates reproductive performance with BMP15. Individuals containing the BMPR1B mutation had significantly higher lambing numbers than the wild type in Small-tailed Han sheep. However, the mode of regulation of BMP15 in the three genotypes (FecB BB, FecB + + and FecB + B) of BMPR1B in the Small-tailed...

Topics

Animals
Female
Granulosa Cells
Cell Proliferation
Signal Transduction
Genotype
Bone Morphogenetic Protein 15
Transforming Growth Factor beta
Sheep
Smad Proteins
Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Bone Morphogenetic Protein Receptors, Type I

Source

Open in PubMed Open full text

Identifiers

PMID: 41998717
DOI: 10.1186/s13048-026-02106-w
PMCID: PMC13220390

Genes

BMP15
BMPR1B
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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