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Article

Association of PHEX Gene Dosage With Meniere Disease and Related Audiovestibular Phenotypes in X-Linked Hypophosphatemia.

JAMA otolaryngology-- head & neck surgery - 1 May 2026

Robles-Bolivar Paula, Bächinger David, Bose Arpan, Ramirez Kimberly, Brown Alison, Juliano Amy F, Lopez-Escamez Jose Antonio, Kujawa Sharon G, Liu Eva S, Amr Sami S, Rauch Steven D, Eckhard Andreas H, Chari Divya A

Abstract excerpt

Importance: Meniere disease (MD) is a heterogenous disorder whose underlying etiologies remain poorly understood. A subtype of MD characterized by endolymphatic sac (ES) underdevelopment (ES hypoplasia), frequent bilateral disease, and male predominance-termed MD-hp-has emerged as a promising model for genetic investigation. Objective: To test whether the PHEX gene underlies the association of XLH with MD-hp....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41989789
DOI: 10.1001/jamaoto.2026.0021
PMCID: PMC13087905

Genes

PHEX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Association of PHEX Gene Dosage With Meniere Disease and Related Audiovestibular Phenotypes in X-Linked Hypophosphatemia.PMID 41989789Read ↗

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