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Article

Genome-wide association analysis of treatment response to onabotulinumtoxinA in Han Chinese patients with chronic migraine: a pilot study.

BMC neurology - 15 Apr 2026

An Yu-Chin, Liang Chih-Sung, Tsai Chia-Kuang, Tsai Chia-Lin, Lin Yu-Kai, Liao Wen-I, Yeh Po-Kuan, Lin Guan-Yu, Hsieh Cheng-Hao, Hung Kuo-Sheng, Yang Fu-Chi

Abstract excerpt

BACKGROUND/OBJECTIVES: OnabotulinumtoxinA (BoNT-A) use is an established preventive treatment for chronic migraine (CM); however, individual response rates vary. Although genetic factors may contribute to this variability, the underlying genetic determinants remain largely undefined, especially in Asian populations. Therefore, we aimed to identify genetic variants associated with the response to BoNT-A treatment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41987076
DOI: 10.1186/s12883-026-04878-6
PMCID: PMC13192000

Genes

TRPC4
GTF2H2
SPOCK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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