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Article

When cytology misses and ultrasound warns: the predictive role of BRAFV600E mutation in thyroid nodules.

Frontiers in endocrinology - 1 Jan 2026

Jie Liu, Wenqing Cai, Guang Zhang, Shijie Li, Qingfeng Fu, Kangping Li, Yuexin Yu, Zhuo Chen, Colombo Carla, Brucchi Francesco, Dionigi Gianlorenzo, Xiaoli Liu

Abstract excerpt

Purpose: Thyroid nodules with high-suspicion ultrasound features but benign cytologic findings remain a diagnostic challenge due to potential false-negative fine-needle aspiration (FNA) results. The BRAFV600E mutation, a hallmark of papillary thyroid carcinoma (PTC), may improve malignancy risk stratification. This study prospectively evaluated the diagnostic performance of BRAFV600E mutation testing in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Predictive Value of Tests

Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Cancer, Papillary

Share to Thyroid Neoplasms

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Source

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Identifiers

PMID: 41982771
DOI: 10.3389/fendo.2026.1803314
PMCID: PMC13070763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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