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Article

Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Recurrent Pregnancy Loss: a Case-Control Study.

Journal of Korean medical science - 1 Dec 2017

Hwang Kyu Ri, Choi Young Min, Kim Jin Ju, Lee Sung Ki, Yang Kwang Moon, Paik Eun Chan, Jeong Hyeon Jeong, Jun Jong Kwan, Yoon Sang Ho, Hong Min A

Abstract excerpt

The balance between coagulation and fibrinolysis is an essential part in early pregnancy. Mutations in methylenetetrahydrofolate reductase (MTHFR) gene lead to decreased activity of the enzyme and hyperhomocysteinemia, which then induces platelet aggregation by promoting endothelial oxidative damage, possibly resulting in adverse effect on maintenance of pregnancy. We investigated the role of MTHFR single...

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Identifiers

PMID: 29115087
DOI: 10.3346/jkms.2017.32.12.2029
PMCID: PMC5680504

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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