Article
Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study.
BMC medicine - 10 Apr 2026
Tranberg Mette, Van Keer Severien, Hesselink Albertus T, Nørgaard Pia, Brøndum Rikke, Wu Chunsen, Gustafson Line Winther, Hammer Anne, Bor Pinar, Binderup Karen Omann, Blach Christina, Vorsters Alex, Steenbergen Renske
Abstract excerpt
BACKGROUND: First-void urine (FVU) collection for high-risk human papillomavirus (HPV) testing may reach un(der)-screened women in cervical cancer screening programs. This cross-sectional study investigated the clinical performance of DNA methylation markers ASCL1 and LHX8 in HPV-positive FVU for detecting high-grade cervical intraepithelial neoplasia and cancer (CIN2+ and CIN3+). Additionally, results were...
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