Article
Development of a novel, urine-based high-risk human papillomavirus polymerase chain reaction test to predict cervical intraepithelial neoplasia abnormalities associated with cervical cancer.
Microbiology spectrum - 7 Jul 2026
Saini Vasu, Guo Zhengyang, Yu Jinwen, Wu Di, Du Hui, Yin Peng, Mosley Garrett Lee, Dai Wenkui, Chiu Ricky Yin To
Abstract excerpt
This study evaluated and optimized a novel urine-based workflow using high-risk human papillomavirus (hrHPV) polymerase chain reaction (PCR) test to detect 14 hrHPV genotypes linked to cervical intraepithelial neoplasia (CIN) abnormalities for cervical cancer screening. In cohort 1 for clinical feasibility, 82 women with confirmed CIN2+ abnormalities provided paired urine and cervical brush samples before...
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