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Article

Machine learning-based clustering differentiates bilateral hepatocellular carcinoma characteristics and prognosis.

Surgery - 1 Jun 2026

Endo Yutaka, Kawashima Jun, Chatzipanagiotou Odysseas, Woldesenbet Selamawit, Aucejo Federico, Marques Hugo P, Lam Vincent, Lesurtel Mickaël, Popescu Irinel, Weiss Matthew, Martel Guillaume, Poultsides George A, Ruzzenente Andrea, Endo Itaru, Gleisner Ana, Shen Feng, Pawlik Timothy M

Abstract excerpt

BACKGROUND: Bilateral hepatocellular carcinoma represents a biologically heterogeneous disease with uncertain optimal surgical selection criteria. Although hepatic resection can provide survival benefit in selected patients, outcomes remain variable, and phenotypic determinants of prognosis have not been clearly defined. METHODS: Patients who underwent curative-intent hepatectomy for bilateral hepatocellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41955886
DOI: 10.1016/j.surg.2026.110186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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