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Article

miRNA profiling of a mutation-negative PKD cohort reveals PKD1/PKD2 ADPKD shared signatures and differences.

Epigenomics - 1 Apr 2026

De Felice Bruna, Nigro Ersilia, Amicone Maria, Pisani Antonio, Daniele Aurora, Farinella Federica

Abstract excerpt

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by mutations in PKD1 or PKD2 genes, but a subgroup of patients has no detectable mutation and remains understudied. We profiled microRNAs (miRNAs) in this mutation-negative group and compared them with PKD1, PKD2, and healthy controls. METHODS: Targeted miRNA profiling was used to measure miRNAs expression. We tested five...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polycystic Kidney, Autosomal Dominant

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Source

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Identifiers

PMID: 41928552
DOI: 10.1080/17501911.2026.2652277
PMCID: PMC13166239

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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