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HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana

1 Feb 2024

Abstract excerpt

The ribosome-tethered N-terminal acetyltransferase A (NatA) acetylates 52% of soluble proteins in Arabidopsis thaliana. This co-translational modification of the N terminus stabilizes diverse cytosolic plant proteins. The evolutionary conserved Huntingtin yeast partner K (HYPK) facilitates NatA activity in planta, but in vitro, its N-terminal helix α1 inhibits human NatA activity. To dissect the regulatory...

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PMID: 38363676
DOI: 10.1016/j.celrep.2024.113768

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