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Article

Comprehensive phenotypic and clonality analysis of intraepithelial lymphocytes of intestinal T-cell lymphoma and chronic enteropathy in dogs.

Veterinary pathology - 1 Sept 2026

Kojima Kazuhiro, Chambers James K, Nakashima Ko, Goto-Koshino Yuko, Uchida Kazuyuki

Abstract excerpt

Canine intestinal T-cell lymphoma (ITCL) may arise from intraepithelial lymphocyte (IEL) subsets expanded in chronic enteropathy (CE). To investigate this potential cell of origin, we performed flow cytometry, immunohistochemistry, and RNA in situ hybridization on IELs using biopsy samples from 62 dogs, including 6 large-cell lymphomas (LCLs), 9 small-cell lymphomas (SCLs), 31 CEs with increased IELs (IEL+CE),...

Read the complete abstract on PubMed

Topics

Animals
Dogs
Dog Diseases
Intraepithelial Lymphocytes
Lymphoma, T-Cell
Flow Cytometry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Intestinal Neoplasms

Immunohistochemistry

In Situ Hybridization

Female

Male

Immunophenotyping

Phenotype

Chronic Disease

Source

Identifiers

PMID: 41913572
DOI: 10.1177/03009858261428495

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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