Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exosomal miR-2110 from PM2.5-Exposed Lung Epithelial Cells Targets SRSF1 to Promote M1 Macrophage Polarization and Inflammatory Responses in COPD.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Miao Yehong, Gu Jianjun, Li Juan, Sheng Danye

Abstract excerpt

Purpose: Exposure to PM2.5 is a known contributor to the development of chronic obstructive pulmonary disease (COPD). As direct targets of PM2.5, bronchial epithelial cells participate in intercellular communication with macrophages and induce phenotypic changes in these immune cells. This study aimed to investigate the role and underly mechanism of epithelial cell-derived exosomes in regulating macrophage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exosomes

Share to Inflammation Mediators

Share to Macrophage Activation

Share to Particulate Matter

Share to Pulmonary Disease, Chronic Obstructive

Share to Serine-Arginine Splicing Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 41909479
DOI: 10.2147/COPD.S584536
PMCID: PMC13032734

Genes

SRSF1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exosomal miR-2110 from PM2.5-Exposed Lung Epithelial Cells Targets SRSF1 to Promote M1 Macrophage Polarization and Inflammatory Responses in COPD.PMID 41909479Read ↗

Exosomal miRNAs-mediated macrophage polarization and its potential clinical application.Semantic proximity Read ↗

Macrophage Polarization and Functions in Pathogenesis of Chronic Obstructive Pulmonary DiseaseSemantic proximity Read ↗

Exosomal miR‑301a‑3p of airway epithelial cells regulates macrophage polarization and promotes lung injury via the GATA1 pathway in acute respiratory distress syndromeSemantic proximity Read ↗

Roles of Macrophage Polarization and Macrophage-Derived miRNAs in Pulmonary FibrosisSemantic proximity Read ↗

Exosomal miR-380 derived from alveolar macrophages in COPD is involved in enhanced proliferation of human bronchial epithelial cellsSemantic proximity Read ↗

The Potential Roles of Exosomes in Chronic Obstructive Pulmonary DiseaseSemantic proximity Read ↗

Smoking-Dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of Chronic Obstructive Pulmonary DiseaseSemantic proximity Read ↗

Particulate matter-induced epigenetic modifications and lung complications.Semantic proximity Read ↗

The effects for PM2.5 exposure on non-small-cell lung cancer induced motility and proliferationSemantic proximity Read ↗

Transcriptome analysis identifies IL24 as an autophagy modulator in PM2.5 caused lung dysfunctionSemantic proximity Read ↗

Lung microbiome and transcriptome reveal mechanisms underlying PM2.5 induced pulmonary fibrosisSemantic proximity Read ↗

Exosome-mediated miR-33 transfer induces M1 polarization in mouse macrophages and exerts antitumor effect in 4T1 breast cancer cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.