Article
Divergent Pathogenesis of 2 Chinese Crimean-Congo Hemorrhagic Fever Viruses in Cynomolgus Macaques.
The Journal of infectious diseases - 2 Sept 2026
Rao Juhong, Yao Yanfeng, Hu Xue, Jiang Tingting, Zhang Zihan, Gao Ge, Liu Hang, Peng Yun, Chen Miaoyu, Liu Jia, Wang Xi, Wang Manli, Deng Fei, Hu Zhihong, Yuan Zhiming, Shan Chao
Abstract excerpt
BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) is a highly pathogenic tick-borne disease with mortality rates of 5% to 82%. Although cynomolgus macaques models exist for Hoti and Afghanistan strains, Chinese CCHFV isolates remain insufficiently defined. METHODS: We evaluated the pathogenicity of 2 Chinese CCHFV strains in cynomolgus macaques: BA04032 (tick-derived) and 75024 (non-lethal human clinical...
Read the complete abstract on PubMedTopics
- Animals
- Macaca fascicularis
- Hemorrhagic Fever Virus, Crimean-Congo
- Hemorrhagic Fever, Crimean
- Disease Models, Animal