Genetic heterogeneity and pathogenic potential of historical Crimean-Congo hemorrhagic fever virus isolates in China.

doi:10.1016/j.virs.2026.07.012

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Article

Genetic heterogeneity and pathogenic potential of historical Crimean-Congo hemorrhagic fever virus isolates in China.

Virologica Sinica - 1 Aug 2026

Moming Abulimiti, Bai Yuan, Zhu Qiong, Jin Jiayin, Fang Yaohui, Huang Shouwei, Wu Qiaoli, Su Zhengyuan, Zhao Guoyu, Tang Shuang, Wang Manli, Hu Zhihong, Zhang Yujiang, Deng Fei, Shen Shu

Abstract excerpt

The Crimean-Congo hemorrhagic fever virus (CCHFV) poses a significant public health threat. In China, CCHFV has been circulating for decades, yet the genomic diversity and pathogenic potential of the circulating strains remain poorly characterized, hindering risk assessment and countermeasure development. In this study, we recovered 24 historical CCHFV strains isolated between 1966 and 2004 from humans, ticks and...

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Topics

Animals
Hemorrhagic Fever Virus, Crimean-Congo
China
Humans
Phylogeny
Hemorrhagic Fever, Crimean

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Genotype

Ticks

Genetic Variation

Genome, Viral

Mice, Inbred C57BL

Virus Replication

Cricetinae

Virulence

Cell Line

Whole Genome Sequencing

Female

Source

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Identifiers

PMID: 42537986
DOI: 10.1016/j.virs.2026.07.012
PMCID: PMC13556321

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