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Article

Predisposition to ALL and Solid Tumors Rather Than Bone Marrow Failure in FANCM-Associated Fanconi Anemia.

JCO precision oncology - 1 Mar 2026

Pegoraro Francesco, Larcher Lise, Kim Rathana, Pagès Mélanie, Passet Marie, Caye-Eude Aurélie, Fahd Mony, Brethon Benoit, Hernandez Lucie, Vasquez Nadia, Da Costa Mélanie, Auger Nathalie, Lachaud Christophe, de Tersant Marie, Luporsi Elisabeth, Sébert Marie, Dalle Jean-Hugues, Peffault de Latour Régis, Clappier Emmanuelle, Stoppa-Lyonnet Dominique, Leblanc Thierry, Paillard Catherine, Sicre de Fontbrune Flore, Soulier Jean

Abstract excerpt

PURPOSE: Fanconi anemia (FA) is a genetic disorder typically characterized by progressive bone marrow failure (BMF) during childhood, leading to diagnosis at that stage. In adolescence or adulthood, patients are predisposed to myelodysplastic syndrome (MDS), acute myeloid leukemia, and solid tumors. However, some individuals present atypically, delaying FA recognition and resulting in life-threatening...

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Identifiers

PMID: 41881068
DOI: 10.1200/PO-25-01089

Genes

FANCM
BMF
BCL11B
HOXA13
ZNF384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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