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Integrative genomic analysis of missense mutations and target genes in hemorrhoid pathogenesis.

Folia medica - 26 Feb 2026

Syaifulanwar Alauddin, Pajrianti Lian, Yulis Hamidy Muhammad, Ismawati Ismawati, Darmawi Darmawi, Muhammad Irham Lalu, Adikusuma Wirawan

Abstract excerpt

INTRODUCTION: Hemorrhoids are a prevalent anorectal condition characterized by the enlargement and displacement of anal cushions. While environmental and lifestyle factors are well-established contributors, emerging evidence suggests a genetic predisposition involving connective tissue integrity and smooth muscle dysfunction. However, the specific genetic variants contributing to hemorrhoid pathogenesis remain...

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PMID: 41879548
DOI: 10.3897/folmed.68.e166557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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