Genetic testing for hereditary breast and ovarian cancer in the Murcian population using a comprehensive NGS panel.

doi:10.1007/s10689-026-00544-5

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Genetic testing for hereditary breast and ovarian cancer in the Murcian population using a comprehensive NGS panel.

Familial cancer - 23 Mar 2026

Mestre Terkemani Y, Rosado Jiménez L, García Aliaga A, Sarabia Meseguer M D, Marín Vera M, Macías Cerrolaza J A, Sánchez Henarejos P, García Hernández M R, Zafra Poves M, Alvarez Abril B, García Torralba E, López Sánchez C B, Moya Martínez M P, Moreno Locubiche M A, Sánchez Martínez D A, Quirós Figelló T A, Cerón Moreno A M, Expósito García M, Antón Martínez D, Martínez Barba E, Ayala de la Peña F, Alonso Romero J L, Noguera Velasco J A, Ruiz Espejo F

Abstract excerpt

Traditionally, hereditary breast and ovarian cancer syndrome (HBOC) has been associated with germline pathogenic or likely pathogenic variants (PV/LPV) in BRCA1 and BRCA2. However, growing evidence indicates that this condition is genetically heterogeneous, and that PV/LPV in additional cancer predisposition genes also contribute significantly to disease susceptibility. In this study, 414 HBOC index cases (ICs)...

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PMID: 41870673
DOI: 10.1007/s10689-026-00544-5

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BRCA1
BRCA2

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