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Article

Evasion of humoral immune responses by a key mutational region of the S2 subunit in PEDV variants.

mBio - 8 Apr 2026

Liu Shiyu, Zhang Gege, Xie Jingyuan, Yuan Boshui, Guo Weilu, Li Yunchuan, Guo Rongli, Sun Min, Hu Mi, Zhao Yongxiang, Liu Fei, Peng Qi, Li Bin, Fan Baochao

Abstract excerpt

Since 2010, millions of piglets have died from porcine epidemic diarrhea virus (PEDV) variant strains. Compared with classical strains, variants exhibit enhanced virulence and immune evasion capacity, rendering classical strain-based vaccines poorly effective. However, the critical mutants responsible for increased pathogenicity and immune evasion remain unclear. This study aims to identify the key mutations that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spike Glycoprotein, Coronavirus

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Source

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Identifiers

PMID: 41870045
DOI: 10.1128/mbio.00026-26
PMCID: PMC13059768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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