Isolation and characterization of a highly virulent novel grass carp reovirus genotype II (GCRV-XT256) for vaccine development.

Abstract excerpt

Grass carp hemorrhagic disease, caused by genotype II grass carp reovirus (GCRV-II), is a devastating disease that leads to high mortality in farmed grass carp. However, the absence of a standardized, high-virulence challenge strain that reliably recapitulates severe disease has hindered pathogenesis and vaccine research. Here, we report the isolation and characterization of a novel GCRV-II strain, GCRV-XT256....

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