Article
CALM1, CALM2, and CALM3 expression and translation efficiency provide insight into the severity of calmodulinopathy.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 30 Mar 2026
Christiansen Steffan Noe Niikanoff, Jacobsen Stine Bøttcher, Andersen Jeppe Dyrberg, Cui Ya, Li Wei, Staehr Christian, Andersen Mikkel Meyer, Crotti Lia, Spazzolini Carla, Schwartz Peter J, Nyegaard Mette, Overgaard Michael Toft
Abstract excerpt
AIMS: Missense variants in the CALM1, CALM2, and CALM3 genes cause calmodulinopathy, which is characterized by ventricular arrhythmias and sudden cardiac death. Although the three genes encode an identical protein, their individual roles and gene-specific clinical implications remain poorly understood. We aimed to determine the relative contribution from each of the genes to the total calmodulin amount and assess...
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