Article
[Multiple endocrine neoplasia syndrome type 1: analysis of data from 102 patients from 43 families in the population of the Russian Federation].
Problemy endokrinologii - 7 Mar 2026
Salimkhanov R Kh, Eremkina A K, Bagirova H V, Meirambek K, Popov S V, Mokrysheva N G
Abstract excerpt
BACKGROUND: Multiple endocrine neoplasia syndrome type 1 (MEN-1) is a rare, autosomal dominant disorder resulting from inactivating mutations in the MEN1 gene. It demonstrates high penetrance, with the "classic triad" of manifestations comprising primary hyperparathyroidism (PHPT), gastrointestinal neuroendocrine neoplasms (NEN), and pituitary adenomas. Diagnosis relies on clinical, familial, and genetic...
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