Double-negative feedback loop between IGF2BP2 and miR-196-5p inhibits the proliferation and differentiation of primary chicken myoblasts.

Abstract excerpt

Skeletal muscle, the primary edible component of chicken, plays a crucial role in determining meat yield and quality. It was reported that IGF2BP2 plays a critical role in the growth and development of mammals muscle, but its role in poultry muscle development remains poorly understood. Here, we investigated the genetic polymorphism of IGF2BP2 in chickens and identified 43 single nucleotide polymorphisms (SNPs),...

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