HOTTIP-Variants in Liver Cancer Metastasis Prognosis: A Clinical Study with Bioinformatics and siRNAs Targeting HOTTIP-WDR5 via Molecular Docking, a Step-Toward ncRNA Precision.

Abstract excerpt

Early detection of hepatocellular carcinoma (HCC) remains challenging due to limitations including the lack of reliable biomarkers. While molecular diagnostics hold promise, their use is limited because tissue biopsies are not routinely performed in HCC. Long non-coding RNAs (lncRNA), such as HOXA transcript at the distal tip (HOTTIP), have been implicated in HCC, with single-nucleotide polymorphisms forming...

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