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Article

A potential association of SLC2A9 variant rs7442295 with uric acid at baseline and in interaction with iloperidone.

The pharmacogenomics journal - 13 Mar 2026

Smieszek Sandra P, Chadwick Sean R, Czeisler Emily L, Torres Rosarelis, Bai Haimeng, Xiao Changfu, Polymeropoulos Christos M, Birznieks Gunther, Polymeropoulos Mihael H

Abstract excerpt

Circulating levels of uric acid are influenced by a complex mix of intrinsic and environmental factors, including genetics, diet, and drugs. We analyzed levels of uric acid in a recent phase 3 clinical trial of patients with bipolar mania treated with 24 mg/day of the antipsychotic iloperidone or placebo. Initial results revealed that iloperidone treatment was associated with increases in uric acid from baseline...

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Identifiers

PMID: 41826282
DOI: 10.1038/s41397-026-00402-8
PMCID: PMC12987721

Genes

SLC2A9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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