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Article

Emergence of artemisinin-based combination therapy resistance markers in Plasmodium falciparum from the Brazilian tri-border region of the Guiana Shield.

Antimicrobial agents and chemotherapy - 1 Apr 2026

Salazar Yanka E A R, Rezende Antonio M, Puça Maria C S B, Louzada Jaime, Mascarenhas Maria E P, Lagström Sonja, Fletcher Danielle, Oliveira-Ferreira Joseli, Gil José P, de Sousa Tais N

Abstract excerpt

Plasmodium falciparum malaria remains a public health concern in the Brazilian Amazon, particularly among mobile and remote populations. Antimalarial drug resistance threatens elimination efforts, particularly in the Guiana Shield, which has historically been linked to the spread of resistant parasites. We analyzed 99 P. falciparum isolates collected in Roraima State, northern Brazil (2016-2020), using targeted...

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PMID: 41817181
DOI: 10.1128/aac.01525-25
PMCID: PMC13041304

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