Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-Guided Risk Stratification of Mitral Valve Surgery in Marfan Syndrome.

Journal of the American College of Cardiology - 23 Jun 2026

Kawashima Yuki, Takeda Norifumi, Omori Akiharu, Nogimori Yoshitsugu, Shiraga Kazuhiro, Masuda Hitomi, Yagi Hiroki, Taniguchi Yuki, Yamauchi Haruo, Ono Minoru, Inuzuka Ryo

Abstract excerpt

BACKGROUND: Although genotype-based risk stratification for aortic disease has been extensively studied in Marfan syndrome (MFS), mitral valve disease has received less attention despite being a major cardiovascular complication requiring surgery in up to 16% of cases. OBJECTIVES: The authors aimed to evaluate genotype-specific differences in mitral valve disease progression and surgical intervention to inform...

Topics

Join the communities discussing this publication.

Adipokines
Adolescent
Fibrillin-1
Genotype
Marfan Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Assessment

Source

Identifiers

PMID: 41811274
DOI: 10.1016/j.jacc.2026.01.059

Genes

FBN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-Guided Risk Stratification of Mitral Valve Surgery in Marfan Syndrome.PMID 41811274Read ↗

Clinical and Phenotypic Correlates of Mitral Valve Prolapse in Marfan Syndrome: The Cornell Aortic Aneurysm Registry.Semantic proximity Read ↗

Clinical relevance of genotype-phenotype correlations beyond vascular events in a cohort study of 1500 Marfan syndrome patients with FBN1 pathogenic variants.Semantic proximity Read ↗

Challenges in Prompt Identification and Surgical Correction of Marfan Syndrome Aortic Disease in a middle-income Country: A Case Series Study.Semantic proximity Read ↗

Genotype impacts survival in Marfan syndrome.Semantic proximity Read ↗

Toward Precision Medicine in Aortopathies: Genetic Insights from a Brazilian Cohort Through Targeted Next-Generation SequencingSemantic proximity Read ↗

Genotype-phenotype spectrum and prognosis of early-onset Marfan syndrome.Semantic proximity Read ↗

Cardiovascular manifestations in men and women carrying a FBN1 mutation.Semantic proximity Read ↗

Late diagnosis of Marfan syndrome is associated with unplanned aortic surgery and cardiovascular deathSemantic proximity Read ↗

Marfan syndrome.Semantic proximity Read ↗

Genetic insights from a Brazilian cohort of aortopathies through targeted next-generation sequencing and FBN1 direct sequencing.Semantic proximity Read ↗

FBN1 gene mutation characteristics and clinical features for the prediction of mitral valve disease progression.Semantic proximity Read ↗

Optimising the mutation screening strategy in Marfan syndrome and identifying genotypes with more severe aortic involvement.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.