Article
FBN1 gene mutation characteristics and clinical features for the prediction of mitral valve disease progression.
International journal of cardiology - 30 Sept 2013
Kühne Kristin, Keyser Britta, Groene Eike F, Sheikhzadeh Sara, Detter Christian, Lorenzen Viktoria, Hillebrand Mathias, Bernhardt Alexander M J, Hoffmann Boris, Mir Thomas S, Robinson Peter N, Berger Jürgen, Reichenspurner Hermann, von Kodolitsch Yskert, Rybczynski Meike
Abstract excerpt
BACKGROUND: Until today, FBN1 gene mutation characteristics were not compared with clinical features for the prediction of mitral valve disease progression. METHODS: Therefore, we conducted a study of 116 patients (53 men, 63 women aged 33 ± 15 years) with a causative FBN1 gene mutation and ≤ moderate mitral valve regurgitation at baseline. RESULTS: During 7.4 ± 6.8 years 30 patients developed progression of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.