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Article

In silico structural and functional characterization of high-risk missense variants in MMP8, GZMK, and OASL genes associated with epidemic viral infections.

Scientific reports - 10 Mar 2026

Et-Tanjaouy Mohamed, Saih Asmae, Machich Omar, Guendouzi Abdelkrim, Zaid Younes, Abdelmoumen Hanaa

Abstract excerpt

This research explores the structural and functional consequences of high-impact missense variants in three immune-related genes MMP8 (D253N, Y261S), GZMK (A42P, L122P), and OASL (W216C) with possible relevance to host response in epidemic viral infections. A layered computational workflow was implemented to predict pathogenicity, evaluate structural stability, and assess residue conservation. Subsequent modeling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41807577
DOI: 10.1038/s41598-026-40467-w
PMCID: PMC13096161

Genes

GZMK
MMP8
OASL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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