Article
High stability of the genome of Akkermansia muciniphila MucT under long-term culturing conditions.
Microbiology spectrum - 7 Apr 2026
Ligthart Kate, Elzinga Janneke, Segers Anneleen, Smidt Hauke, de Vos Willem M
Abstract excerpt
To advance our understanding of the genomic stability of Akkermansia muciniphila, its type strain MucT was grown for over 1,000 generations at five different culturing conditions, followed by the isolation of single colonies and their subsequent genomic DNA sequencing, physiological, and functional analysis. Notably, not a single mutation was found in the genomes using our sequencing approach of the dozen strains...
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