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Article

Generation of hiPSCs lines from PRICKLE2-mutant individuals with epilepsy.

Stem cell research - 1 Apr 2026

Zannino Clara, Esposito Antonella, Talarico Mariagrazia, Fortunato Francesco, Benedetto Giorgia, Sammarra Ilaria, Parrotta Elvira Immacolata, Gambardella Antonio, Cuda Giovanni

Abstract excerpt

The PRICKLE2 gene encodes a protein implicated in the non-canonical Wnt signalling pathway and in the regulation of planar cell polarity, although its precise biological functions remain incompletely understood. To date, only few PRICKLE2 mutations have been reported, and these have been associated with diverse clinical phenotypes, including autism spectrum disorders, epilepsy, and neurodevelopmental delay1. Here...

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Identifiers

PMID: 41794019
DOI: 10.1016/j.scr.2026.103953

Genes

PRICKLE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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