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Generation of a human iPSC line (MPIi006-A) from a patient with Pelizaeus-Merzbacher disease.

Stem cell research - 1 Jul 2020

Kim Kee-Pyo, Yoon Juyong, Shin Borami, Röpke Albrecht, Han Dong Wook, Schöler Hans R

Abstract excerpt

We established a human induced pluripotent stem cells (hiPSC) line (MPIi006-A) from fibroblasts of a 20-year-old male Pelizaeus-Merzbacher disease (PMD) patient with a hemizygous 643C>T mutation in proteolipid protein 1 (PLP1) gene using a retroviral delivery of OCT4, SOX2, KLF4 and c-MYC. The MPIi006-A iPSC line carried the mutation, displayed typical iPSC morphology, expressed pluripotent stem cell makers,...

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Fibroblasts
Induced Pluripotent Stem Cells
Kruppel-Like Factor 4
Mutation
Myelin Proteolipid Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pelizaeus-Merzbacher Disease

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PMID: 32446239
DOI: 10.1016/j.scr.2020.101839

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