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Article

Validation of ICC hierarchical classification in secondary AML.

Blood advances - 26 May 2026

Attardi Enrico, Cipriani Marta, Guarnera Luca, Savi Arianna, Fabiani Emiliano, Mallegni Flavia, Moretti Federico, Silvestrini Giorgia, Awada Hussein, Durmaz Arda, Ferrari Ivan, Maggioni Giulia, Memoli Mara, Visconte Valeria, Venditti Adriano, Della Porta Matteo Giovanni, Gurnari Carmelo, Piciocchi Alfonso, Maciejewski Jaroslaw P, Voso Maria Teresa

Abstract excerpt

ABSTRACT: Secondary acute myeloid leukemia (AML) comprises heterogeneous entities, unified by poor prognosis. We evaluated the associations of genetic profiles with blast counts and patients' history in a cohort of 924 patients with myelodysplastic syndrome (MDS)/AML or AML, classified according to the International Consensus Classification (ICC). The cohort included 109 patients with "mutated TP53," 497 with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41785326
DOI: 10.1182/bloodadvances.2025018188
PMCID: PMC13194593

Genes

ELN
TP53
ASXL1
SRSF2
STAG2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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