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Integrative genomic and clinical analysis of carbapenem-resistant and susceptible Klebsiella pneumoniae isolates from a tertiary hospital in Wuhan.

Frontiers in cellular and infection microbiology - 1 Jan 2026

Liu Mengling, Wu Zhiyong, Mao Jieyu, Zhang Shuo, Xu Sheng, Min Jinwen, Yu Wenjing, Liu Haizhou, Hu Yangbo, Wu Xiaojun

Abstract excerpt

Objectives: Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a major global health threat due to its resistance to carbapenems. As the mechanisms underlying carbapenem resistance in CRKP remain incompletely understood, we seek to provide important insights into the clinical and genomic characteristics of CRKP. Methods: A total of 40 CRKP and 42 carbapenem-susceptible Klebsiella pneumoniae (CSKP)...

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Identifiers

PMID: 42656273
DOI: 10.3389/fcimb.2026.1881548
PMCID: PMC13506390

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