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Article

Real-world outcomes of encorafenib, cetuximab ± binimetinib for BRAF‑mutated metastatic colorectal cancer: the BEETS (JACCRO CC‑18) study.

The oncologist - 9 Mar 2026

Kotani Daisuke, Inoue Eisuke, Denda Tadamichi, Inagaki Chiaki, Kashiwada Tomomi, Mihara Yoshiaki, Sugaya Akinori, Suwa Yusuke, Ohta Takashi, Kuramochi Hidekazu, Oshima Kotoe, Yuki Satoshi, Shiozawa Manabu, Tsuji Akihito, Muro Kei, Ichikawa Wataru, Fujii Masashi, Sunakawa Yu

Abstract excerpt

BACKGROUND: Triplet therapy (encorafenib, cetuximab, and binimetinib) is recommended in Japan for BRAF V600E mutated metastatic colorectal cancer (mCRC) patients with poor prognostic factors (PFs) based on subgroup analyses of the BEACON CRC trial. We, therefore, conducted a nationwide prospective observational study to evaluate the real-world effectiveness of triplet versus doublet therapy (encorafenib plus...

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PMID: 41761577
DOI: 10.1093/oncolo/oyag068
PMCID: PMC13006056

Genes

BRAF

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