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Article

Encorafenib, binimetinib, and cetuximab in BRAF V600E-mutated colorectal cancer: an early post-marketing phase vigilance study.

International journal of clinical oncology - 1 Jan 2023

Sakata Hidenori, Murase Maki, Kato Takeshi, Yamaguchi Kensei, Sugihara Kenichi, Suzuki Shigenobu, Yoshino Takayuki

Abstract excerpt

BACKGROUND: Triplet and doublet regimens of encorafenib plus cetuximab with and without binimetinib, respectively, were approved in Japan for unresectable, metastatic, BRAF V600E-mutated colorectal cancer (mCRC) that had progressed after 1-2 prior chemotherapies. This early post-marketing phase vigilance (EPPV) study collected adverse drug reactions (ADRs) from Japanese patients to ensure safety measures as...

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Identifiers

PMID: 36355316
DOI: 10.1007/s10147-022-02264-z
PMCID: PMC9823055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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