Encorafenib Plus Cetuximab as a New Standard of Care for Previously Treated BRAF V600E-Mutant Metastatic Colorectal Cancer: Updated Survival Results and Subgroup Analyses from the BEACON Study.

doi:10.1200/JCO.20.02088

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Article

Encorafenib Plus Cetuximab as a New Standard of Care for Previously Treated BRAF V600E-Mutant Metastatic Colorectal Cancer: Updated Survival Results and Subgroup Analyses from the BEACON Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 2021

Tabernero Josep, Grothey Axel, Van Cutsem Eric, Yaeger Rona, Wasan Harpreet, Yoshino Takayuki, Desai Jayesh, Ciardiello Fortunato, Loupakis Fotios, Hong Yong Sang, Steeghs Neeltje, Guren Tormod Kyrre, Arkenau Hendrik-Tobias, Garcia-Alfonso Pilar, Elez Elena, Gollerkeri Ashwin, Maharry Kati, Christy-Bittel Janna, Kopetz Scott

Abstract excerpt

PURPOSE: BEACON CRC evaluated encorafenib plus cetuximab with or without binimetinib versus investigators' choice of irinotecan or FOLFIRI plus cetuximab in patients with BRAFV600E-mutant metastatic colorectal cancer (mCRC), after progression on 1-2 prior regimens. In the previously reported primary analysis, encorafenib, binimetinib plus cetuximab (ENCO/BINI/CETUX; triplet) and encorafenib plus cetuximab...

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PMID: 33503393
DOI: 10.1200/JCO.20.02088
PMCID: PMC8078423

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