ANCHOR CRC: Results From a Single-Arm, Phase II Study of Encorafenib Plus Binimetinib and Cetuximab in Previously Untreated BRAFV600E-Mutant Metastatic Colorectal Cancer.

doi:10.1200/JCO.22.01693

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Article

ANCHOR CRC: Results From a Single-Arm, Phase II Study of Encorafenib Plus Binimetinib and Cetuximab in Previously Untreated BRAFV600E-Mutant Metastatic Colorectal Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2023

Van Cutsem Eric, Taieb Julien, Yaeger Rona, Yoshino Takayuki, Grothey Axel, Maiello Evaristo, Elez Elena, Dekervel Jeroen, Ross Paul, Ruiz-Casado Ana, Graham Janet, Kato Takeshi, Ruffinelli Jose C, André Thierry, Carrière Roussel Edith, Klauck Isabelle, Groc Mélanie, Vedovato Jean-Claude, Tabernero Josep

Abstract excerpt

PURPOSE: The positive BEACON colorectal cancer (CRC) safety lead-in, evaluating encorafenib + cetuximab + binimetinib in previously treated patients with BRAFV600E-mutated metastatic CRC (mCRC), prompted the design of the phase II ANCHOR CRC study (ClinicalTrails.gov identifier: NCT03693170). ANCHOR CRC aimed to evaluate efficacy, safety, and quality of life with first-line encorafenib + binimetinib + cetuximab...

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PMID: 36763936
DOI: 10.1200/JCO.22.01693
PMCID: PMC10414717

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