Article
Concurrent driver mutations induce distinct tumour morphologies on radiological imaging.
European journal of radiology - 1 May 2026
Rodríguez Sánchez Diana Ivonne, Vanneste Thera, Middelkoop Julian, Maxouri Olga, Rostami Sajjad, Ursprung Stephan, Boveradze Nino, Chupetlovska Kalina, Castagnoli Francesca, Landolfi Federica, Hong Eun Kyoung, Pizzi Andrea Delli, Gennaro Nicolo, Snaebjornsson Petur, Bodalal Zuhir, Beets-Tan Regina
Abstract excerpt
BACKGROUND: Most radiogenomic studies examine single driver mutations in isolation, despite evidence that co-occurring driver alterations are common and functionally interacting in cancer. Whether concurrent mutations produce distinct imaging phenotypes or simply average single-mutation effects remains unknown. METHODS: A multi-cancer cohort of 1235 patients with 8633 segmented lesions from contrast-enhanced CT...
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